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Drugs with narrow therapeutic windows (warfarin, levothyroxine, oral contraceptives, certain seizure medications) deserve clinician oversight

Initial results utilizing combination therapy for patients with a suboptimal response to either alprostadil or sildenafil monotherapy

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Calibration against 100 mM H 2 O 2 to fully oxidize and 10 mM DTT to fully reduce the sensor (Figure 1A and B) and an assumed cytosolic pH of 7.4 led to an estimation of the glutathione redox potential (E GSH ) of - 309mV +/-10 at 20C in palissadic cotyledon cells and to a less negative E GSH to 247 mV +/-21 after 1 hour treatment at 37C

Qian, E., Poojar, P., Vaughan, J

10.1016/s0021-9258(17)34693-8 116 McGarryJ